HTRA 2 ( HtrA serine peptidase 2 )

Note Amplification of 2p13-16 has frequently been found in non-Hodgkin's lymphoma, mediastinal thymic B-cell lymphoma and in some cases of neuroblastoma, ovarian cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer and synovial sarcoma (Knuutila et al., 1998). Translocations and deletions of region 2p12 were found in acute and chronic lymphocytic leukaemias as well as nonlymphocytic leukaemia and Hodgkin disease (Shapiro et al., 1994). Genetic variations on chromosome 2p12-p13 have been associated with the development of Parkinson's disease (Gasser et al., 1998), Miyoshi myopathy, limb-girdle muscular dystrophy (Liu et al., 1998), Welander myopathy (Ahlberg et al., 1999), acute lymphoblastic childhood leukaemia (Inaba et al., 1991), chronic lymphocytic leukaemia (Richardson et al., 1992) and Burkitt's lymphomas (Lenoir et al., 1982).